HIV AIDS - 97 US Medicines in Testing - PharmaTimes

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Updated November 26, 2025

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U.S. Pharmaceutical Companies Developing 97 New Drugs and Vaccines to Fight HIV/AIDS - MedIndia:
https://www.medindia.net/health-press-release/US-Pharmaceutical-Companies-Developing-97-New-Drugs-and-Vaccines-to-Fight-HIVAIDS-53732-1.htm

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This is a really nice snapshot of some of the clinical testing going on in the HIV AIDS field, PhRMA's Pharmaceutical Researchers Are Testing 97 Medicines And Vaccines for HIV and Related Conditions. The article provides a quick overview for medicines grouped by:

1. Anticancer
2. Antiviral
3. Gene therapy
4. Immunomodulators
5. Vaccines
6. Other

Previous Posts: Abzymes Pinpoint The HIV Achilles Heel 109 HIV Drugs And Vaccines Under Development Listen To People With AIDS and HIV (audio)

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The HappyHour Gene - Implications for drinkers

This is an interesting read. University of California, San Francisco scientists have discovered the 'HappyHour' gene, a newly identified gene that makes fruit flies sensitive to booze. This means that drugs that mimic the effects of the gene may offer a new treatment against alcohol abuse. In this NewScientist article, 'Happyhour' gene may help put boozers off their drink, folks say, "People who are very sensitive to alcohol tend to drink less – that's the person who gets drunk on one glass of wine," and "The person who can drink everybody under the table – that's the person who is more likely to become an alcoholic." "Theoretically, a medication that increases the sensitivity to alcohol – that you need to drink less of to get an effect – might be protective," Heberlein says. Read Heberlein's findings in, Cell (DOI: 10.1016/j.ajhg.2009.04.018) - or the Research Abstract. 

Related Posts: Deadly Drinking In College - Drinking Games - Alcohol Deaths 21st Birthday - Extreme Drinking Binges - 12 drink avg for men 

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HIV AIDS - Gene Research Shows Promise

Jay Levy of UCSF wrote a recent editorial in the NEJM (Levy, NEJM, 2/12/09), as reported in this Medical News Today article, New HIV/AIDS Research Directions Show Promise, NEJM Editorial Says. This is the first time I've read about this, and find it incredibly fascinating and exciting. Here are my takeaways from reading the article . . .

1. Recent HIV/AIDS research that examines the role certain genes play in inhibiting HIV progression shows promise for the development of new treatment measures
2. HIV enters the body through CD4+ T cells and then binds to the chemokine receptors CCR5 and CXCR4.
3. Research has found that people whose cells lack expression of the CCR5 gene typically demonstrate resistance to the virus.
4. Researchers examined the case of an HIV-positive patient with myelogenous leukemia who received a bone marrow transplant from a person whose cells lacked expression of the CCR5 gene. After two transplants, the researchers determined that the patient had no leukemia recurrence and no detectable level of HIV in the bloodstream
5. Levy says, "the result of this study [reported in the same NEJM issue] and others provide further encouragement for those examining approaches to treatment that reduce CCR5 [receptor] expression in persons with HIV." This is the study Levy refers to, Brief Report: Long-Term Control of HIV by CCR5 Delta32/Delta32 Stem-Cell Transplantation (summary).

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HIV Treatment Goes Bionic
HHS Updates HIV Treatment Guidelines (free pdf)

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